A Change in Hemoglobins Structure Can Disturb Hemoglobin Function Essa

A Change in Hemoglobin's Structure Can Disturb Hemoglobin Function Abstract: The fact that a molecule?s structure determines its function can be seen through the oxygen transporter protein, hemoglobin. Hemoglobin can take two forms, oxy state and deoxy state, and each performs a distinct function for the hemoglobin. In a normal hemoglobin, the oxygen binds to a heme group during the oxy state and releases oxygen during the deoxy state. However, when hemoglobin is mutated like in sickle cell anemia, in which the amino acid glumatic acid is substituted with valine in the sixth position of beta subunit; the hemoglobin will not function correctly in the deoxy state. This will lead the hemoglobin to take a sickle shape that will eventually cause sickle cell anemia. Imagine doing an internship in the emergency department of the hospital, suddenly, a five year old athlete comes to the ER that is having hard time breathing. The results from the tests that were done on the athlete show that he could not become like his idol, Michel Jordan, in basketball because he has sickle cell anemia. During the talk with one of the doctors that you were working with, you discover that sickle cell anemia is a hereditary disease that occurs due to the deficiency of the red blood cells. This is caused by a genetic mutation in the hemoglobin, an oxygen carrier protein, in which one amino acid is changed to another. This mutation in the structure of the hemoglobin disturbs the proteins? normal function and eventually leads to sickle cell anemia. Have you wondered how this small change in the structure of hemoglobin can cause sickle cell anemia, and 3 stop the athlete from playing basketball? Well, this is one of the main topics that w... ...6um%3D 1%26hl%3Den>. (3)"blood: hemoglobin tetramer." Encyclopedia Britannica. 2007. Encyclopï ¿ ½dia Britannica, Inc. . 27 Jul 2008 . (4) "Porphyrin." The Free Dictionary. Copyright ï ¿ ½ 2008 . Farlex, Inc.. 27 Jul 2008 . (5)DR.JAKUBOWSKI,"CHAPTER5-BINDING."05/16/08.27Jul2008 html>. 6)Voet, Donald. Biochemsitry . 1990. John Wiely , 7, 8) ?How Does Sickle Cell Cause Disease?." April 11, 2002 . harvard . 27 Jul 2008 . 12 Acknowledgments: I acknowledge Dr. Peck, Mike, Bless and my professors from the chemistry cluster: Dean, Tim, and Tobey for always being there for me whenever I needed their help to spark this project. A Change in Hemoglobin's Structure Can Disturb Hemoglobin Function Essa A Change in Hemoglobin's Structure Can Disturb Hemoglobin Function Abstract: The fact that a molecule?s structure determines its function can be seen through the oxygen transporter protein, hemoglobin. Hemoglobin can take two forms, oxy state and deoxy state, and each performs a distinct function for the hemoglobin. In a normal hemoglobin, the oxygen binds to a heme group during the oxy state and releases oxygen during the deoxy state. However, when hemoglobin is mutated like in sickle cell anemia, in which the amino acid glumatic acid is substituted with valine in the sixth position of beta subunit; the hemoglobin will not function correctly in the deoxy state. This will lead the hemoglobin to take a sickle shape that will eventually cause sickle cell anemia. Imagine doing an internship in the emergency department of the hospital, suddenly, a five year old athlete comes to the ER that is having hard time breathing. The results from the tests that were done on the athlete show that he could not become like his idol, Michel Jordan, in basketball because he has sickle cell anemia. During the talk with one of the doctors that you were working with, you discover that sickle cell anemia is a hereditary disease that occurs due to the deficiency of the red blood cells. This is caused by a genetic mutation in the hemoglobin, an oxygen carrier protein, in which one amino acid is changed to another. This mutation in the structure of the hemoglobin disturbs the proteins? normal function and eventually leads to sickle cell anemia. Have you wondered how this small change in the structure of hemoglobin can cause sickle cell anemia, and 3 stop the athlete from playing basketball? Well, this is one of the main topics that w... ...6um%3D 1%26hl%3Den>. (3)"blood: hemoglobin tetramer." Encyclopedia Britannica. 2007. Encyclopï ¿ ½dia Britannica, Inc. . 27 Jul 2008 . (4) "Porphyrin." The Free Dictionary. Copyright ï ¿ ½ 2008 . Farlex, Inc.. 27 Jul 2008 . (5)DR.JAKUBOWSKI,"CHAPTER5-BINDING."05/16/08.27Jul2008 html>. 6)Voet, Donald. Biochemsitry . 1990. John Wiely , 7, 8) ?How Does Sickle Cell Cause Disease?." April 11, 2002 . harvard . 27 Jul 2008 . 12 Acknowledgments: I acknowledge Dr. Peck, Mike, Bless and my professors from the chemistry cluster: Dean, Tim, and Tobey for always being there for me whenever I needed their help to spark this project.